Yes, but with some conditions. Under the U.S.Israel income tax treaty, a contribution to an Israeli charitable organization is deductible if and to the extent the contribution would have been treated as a charitable contribution if the organization had been created or organized under U.S. law. To deduct your contribution to an Israeli charity, you must have income from sources in Israel. The deduction is also limited to 25% of your adjusted gross income from Israeli sources.
Can I Make a Donation to an Israeli Charity and Receive a Deduction?